What is APOE4? A plain-language primer
APOE4 is the most common genetic risk factor for late-onset Alzheimer’s. Here’s what the gene does, what carrying it means, and what it doesn’t mean.
Updated May 20, 2026 7 min read
Deep Dives
APOE4 Basics
What the gene is and what it means for you.
← All topics
APOE4 Basics APOE4 Basics APOE4 Basics APOE4 Basics APOE4 Basics APOE4 Basics
The APOE genotypes explained: from 2/2 to 4/4
You inherit one APOE allele from each parent. Here’s what each of the six combinations, from protective 2/2 to higher-risk 4/4, actually means.
Updated June 2, 2026 6 min read
How to get tested for APOE4, and whether you should
Consumer kits, clinical tests, and genetic counseling compared, plus the psychological and practical trade-offs of learning your APOE status.
Updated June 2, 2026 6 min read
APOE4 myths vs. facts
Carrier forums and headlines spread a lot of half-truths about APOE4. Here are the ones worth correcting, and what the evidence actually supports.
Updated June 2, 2026 6 min read
A plain-English glossary of APOE4 terms
Amyloid, tau, ApoB, ARIA, alleles: the APOE4 world is full of jargon. Here are the terms you’ll keep running into, defined without the textbook density.
Updated June 2, 2026 6 min read
APOE4 and family: should your relatives get tested?
Your genotype carries information about your parents, siblings, and children. How to think about sharing it, and whether relatives should test too.
Updated June 2, 2026 6 min read